Translational readthrough

Across TCGA patient cohorts, RNA activity of the Translational readthrough pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HM13-AS1, LINC02574, and TRBV10-3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational readthrough activity versus HM13-AS1 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HM13-AS1 →	+0.297	+0.484	<.001	.007	3	3
LUAD	LINC02574 →	+0.240	+0.704	.005	.001	3	3
UCEC	TRBV10-3 →	+0.761	+0.731	.005	.002	3	3
BRCA	ZIC5 →	-0.565	-0.286	.002	<.001	3	2
BRCA	MMEL1 →	+0.491	+0.182	<.001	.005	3	2
BRCA	LINC02492 →	-0.157	-0.232	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006451 vs HM13-AS1 — LSCC

Explore this scatter interactively →