Translational readthrough

Across TCGA cell cohorts, RNA activity of the Translational readthrough pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD14A, TGFBR1, and DNAJC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational readthrough activity versus MFSD14A in LARGE_INTESTINE (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MFSD14A →	-1.321	-2.065	.009	<.001	2	3
LARGE_INTESTINE	TGFBR1 →	-1.133	-2.065	.002	<.001	2	2
PANCREAS	DNAJC2 →	+0.825	+0.319	.004	.006	2	1
PANCREAS	ANXA2 →	-1.219	-0.319	.001	.006	2	1
PANCREAS	IRF9 →	-1.920	-0.288	.001	.009	2	1
PANCREAS	DERL3 →	-1.620	-0.401	.003	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006451 vs MFSD14A — LARGE_INTESTINE

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