Regulation of translational termination

Across TCGA patient cohorts, RNA activity of the Regulation of translational termination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX39A, NOP16, and CENPJ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational termination activity versus DDX39A in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX39A →	+0.262	+0.098	.008	.005	3	4
LSCC	NOP16 →	+0.442	+0.180	.001	.001	3	4
LSCC	CENPJ →	+0.597	+0.148	<.001	.006	3	4
COAD	SHPK →	+0.284	+0.114	.002	.005	3	3
UCEC	ENPP5 →	-0.765	-0.103	.009	.003	3	3
LSCC	MRPL4 →	+0.463	+0.188	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006449 vs DDX39A — GBM

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