Regulation of translational elongation

Across TCGA patient cohorts, RNA activity of the Regulation of translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C21orf91, USP25, and USP16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational elongation activity versus C21orf91 in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C21orf91 →	+0.553	+0.128	.004	.003	3	4
LSCC	USP25 →	+0.364	+0.171	<.001	<.001	3	4
LSCC	USP16 →	+0.339	+0.185	<.001	<.001	3	4
LSCC	SYNJ1 →	+0.232	+0.118	<.001	.006	3	4
LSCC	CRYZL1 →	+0.317	+0.135	<.001	.001	3	4
LSCC	ORC3 →	+0.428	+0.189	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006448 vs C21orf91 — LSCC

Explore this scatter interactively →