Regulation of translational initiation

Across TCGA cell cohorts, RNA activity of the Regulation of translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOXA1, SRSF7, and RCC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOXA1 grouped by Regulation of translational initiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NOXA1 →	+1.569	+0.183	.002	.003	3	4
BLOOD_Leukemia	SRSF7 →	-0.702	-0.166	.004	.001	3	4
BLOOD_Leukemia	RCC1 →	-0.748	-0.165	.008	.002	3	4
BREAST	TFDP1 →	-0.671	-0.127	.009	.002	3	4
BLOOD_Myeloma	TXLNG →	-0.703	-0.091	.001	<.001	3	4
KIDNEY	KLHDC3 →	-0.594	-0.170	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOXA1 by Regulation of translational initiation activity — STOMACH

Explore this box plot interactively →