Translational initiation

Across TCGA cell cohorts, RNA activity of the Translational initiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSEN2, MAP1B, and ARFRP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSEN2 grouped by Translational initiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSEN2 →	+0.217	+0.182	.001	.006	3	7
BREAST	MAP1B →	-0.164	-0.142	<.001	.002	3	7
LUNG_NSCLC_LUSC	ARFRP1 →	+0.493	+0.223	.001	.009	3	6
LUNG_NSCLC_LUSC	PTK2B →	+0.287	+0.261	.004	.003	3	6
OVARY	OCA2 →	+0.392	+0.142	.004	.005	3	6
OVARY	SCUBE1 →	+0.433	+0.173	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSEN2 by Translational initiation activity — BLOOD_Leukemia

Explore this box plot interactively →