mRNA export from nucleus

Across TCGA cell cohorts, RNA activity of the mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCL, PRRC2B, and REV1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA export from nucleus activity versus PDCL in LUNG_NSCLC_LUSC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PDCL →	+1.147	+0.106	.001	<.001	3	20
BONE	PRRC2B →	+1.284	+0.122	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	REV1 →	+0.942	+0.084	<.001	<.001	3	19
OVARY	UBXN7 →	+1.201	+0.091	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	RBM12B →	+1.204	+0.128	<.001	.002	3	19
UPPER_AERODIGESTIVE_TRACT	TNRC6A →	+1.406	+0.129	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006406 vs PDCL — LUNG_NSCLC_LUSC

Explore this scatter interactively →