RNA export from nucleus

Across TCGA cell cohorts, RNA activity of the RNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK2, PANO1, and SRSF7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIPK2 grouped by RNA export from nucleus-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RIPK2 →	-1.076	-0.110	<.001	.003	3	5
BONE	PANO1 →	+0.770	+0.081	.001	.001	3	5
CNS	SRSF7 →	-0.303	-0.113	.005	.006	3	4
KIDNEY	CIAPIN1 →	-0.903	-0.191	.001	.001	3	4
KIDNEY	NOB1 →	-1.114	-0.214	<.001	.001	3	4
STOMACH	FAM199X →	-0.754	-0.117	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIPK2 by RNA export from nucleus activity — BONE

Explore this box plot interactively →