RNA localization

Across TCGA patient cohorts, RNA activity of the RNA localization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADNP, CHD4, and AKAP8L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA localization activity versus ADNP in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADNP →	+0.379	+0.060	<.001	<.001	3	6
LSCC	CHD4 →	+0.317	+0.060	<.001	<.001	3	6
UCEC	AKAP8L →	+0.291	+0.050	.003	.005	2	7
HNSC	MBD3 →	+0.366	+0.090	<.001	.001	3	6
LUAD	FOXK1 →	+0.228	+0.025	.001	.004	3	6
HNSC	NCOA5 →	+0.344	+0.097	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006403 vs ADNP — LSCC

Explore this scatter interactively →