RNA localization

Across TCGA pan-cancer cohorts, RNA activity of the RNA localization pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and THCA, show the opposite pattern, with lower activity in tumor tissue.

LIHC, BLCA, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LIHC	All	II,III,IV	+0.037	<.001	9	view →
BLCA	All	All	+0.042	.002	8	view →
HNSC	Male	All	+0.032	<.001	8	view →
LUAD	Male	All	+0.040	<.001	7	view →
KICH	Female	All	−0.050	<.001	6	view →
THCA	All	II,III,IV	−0.032	<.001	6	view →
COAD	All	II,III,IV	+0.020	.001	6	view →
CHOL	Male	All	+0.103	<.001	5	view →
STAD	Male	II,III,IV	+0.051	.002	4	view →
LUSC	Male	All	+0.034	<.001	4	view →
KIRP	All	IV	+0.044	.005	2	view →
PAAD	Male	All	+0.025	.037	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0006403–LIHC

Open the LIHC breakdown →