RNA localization

Across TCGA cell cohorts, RNA activity of the RNA localization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSD, CKS1B, and RFC5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTSD grouped by RNA localization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CTSD →	+2.033	+0.165	<.001	<.001	3	5
SOFT_TISSUE	CKS1B →	-1.061	-0.171	.002	.007	3	5
SOFT_TISSUE	RFC5 →	-0.773	-0.179	.005	.004	3	5
SOFT_TISSUE	TBC1D31 →	-0.499	-0.194	.009	.001	3	5
BLOOD_Leukemia	MRPS9 →	-0.750	-0.177	.001	<.001	3	5
LUNG_NSCLC_LUAD	AZIN2 →	+0.953	+0.113	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTSD by RNA localization activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →