tRNA modification

Across TCGA cell cohorts, RNA activity of the tRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFMID, CASP1, and EPB41, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA modification activity versus AFMID in OVARY (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AFMID →	+0.688	+0.618	.007	.007	3	4
BLOOD_Leukemia	CASP1 →	-2.751	-0.146	<.001	<.001	3	4
BLOOD_Leukemia	EPB41 →	+1.048	+0.130	<.001	.003	3	4
BLOOD_Leukemia	ARL5B →	+0.986	+0.137	.001	.004	3	4
LUNG_SCLC	TAF4B →	+1.313	+0.153	.006	.003	2	5
BLOOD_Lymphoma	VPREB3 →	+5.759	+0.129	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006400 vs AFMID — OVARY

Explore this scatter interactively →