mRNA 3'-end processing by stem-loop binding and cleavage

Across TCGA patient cohorts, RNA activity of the mRNA 3'-end processing by stem-loop binding and cleavage pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, CENPO, and SPC24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA 3'-end processing by stem-loop binding and cleavage activity versus KIF18A in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIF18A →	+0.646	+0.509	.001	.002	3	5
LSCC	CENPO →	+0.555	+0.574	<.001	<.001	3	4
BRCA	SPC24 →	+0.817	+0.519	.001	.003	3	4
BRCA	HMGB2 →	+0.653	+0.628	<.001	<.001	3	4
BRCA	SKA3 →	+0.839	+0.445	.001	.009	3	4
BRCA	EXO1 →	+0.712	+0.474	.008	.006	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006398 vs KIF18A — LSCC

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