Transcription by RNA polymerase III

Across TCGA patient cohorts, RNA activity of the Transcription by RNA polymerase III pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARCL1, HSPB7, and EZH2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription by RNA polymerase III activity versus SPARCL1 in BRCA (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPARCL1 →	-0.864	-0.648	<.001	<.001	3	8
BRCA	HSPB7 →	-0.738	-0.567	<.001	<.001	3	8
GBM	EZH2 →	+0.900	+1.064	<.001	<.001	3	7
GBM	FOXM1 →	+1.013	+1.090	<.001	<.001	3	7
GBM	LMNB1 →	+0.997	+1.032	<.001	<.001	3	7
GBM	KIF14 →	+0.964	+0.925	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006383 vs SPARCL1 — BRCA

Explore this scatter interactively →