mRNA splice site recognition

Across TCGA cell cohorts, RNA activity of the mRNA splice site recognition pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1L2, SINHCAF, and ZNF124, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA splice site recognition activity versus HNRNPA1L2 in KIDNEY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HNRNPA1L2 →	+0.621	+0.216	.001	.005	3	7
BLOOD_Leukemia	SINHCAF →	+0.772	+0.156	<.001	.001	3	7
CNS	ZNF124 →	+0.900	+0.193	<.001	<.001	3	7
KIDNEY	SPINDOC →	+1.069	+0.297	.001	.005	3	6
BREAST	NASP →	+0.797	+0.143	<.001	<.001	3	6
BONE	HNRNPU →	+0.719	+0.177	<.001	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006376 vs HNRNPA1L2 — KIDNEY

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