Transcription initiation at RNA polymerase II promoter

Across TCGA patient cohorts, RNA activity of the Transcription initiation at RNA polymerase II promoter pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSF1, SMC1A, and SRRT, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation at RNA polymerase II promoter activity versus RSF1 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RSF1 →	+0.274	+0.037	<.001	<.001	3	8
HNSC	SMC1A →	+0.271	+0.069	<.001	.002	3	8
LUAD	SRRT →	+0.217	+0.043	<.001	<.001	3	7
HNSC	HCFC1 →	+0.168	+0.051	.004	.002	3	7
LSCC	MORF4L1 →	+0.420	+0.054	<.001	<.001	3	7
HNSC	PHF3 →	+0.253	+0.074	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006367 vs RSF1 — LSCC

Explore this scatter interactively →