Transcription initiation at RNA polymerase I promoter

Across TCGA cell cohorts, RNA activity of the Transcription initiation at RNA polymerase I promoter pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, SCAMP2, and CD63, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation at RNA polymerase I promoter activity versus NASP in LARGE_INTESTINE (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NASP →	+0.680	+0.194	<.001	<.001	3	6
LARGE_INTESTINE	SCAMP2 →	-0.628	-0.186	.005	.008	3	6
LUNG_NSCLC_LUSC	CD63 →	-1.415	-0.483	.003	.001	3	6
LUNG_NSCLC_LUSC	TMBIM4 →	-1.405	-0.466	.001	.003	3	6
LUNG_NSCLC_LUSC	HEXA →	-1.235	-0.480	.007	.002	3	6
STOMACH	KRI1 →	+1.327	+0.349	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006361 vs NASP — LARGE_INTESTINE

Explore this scatter interactively →