DNA-templated transcription termination

Across TCGA cell cohorts, RNA activity of the DNA-templated transcription termination pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBB, UFC1, and SELENBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated transcription termination activity versus INHBB in OESOPHAGUS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	INHBB →	-2.053	-0.186	<.001	.004	3	4
OESOPHAGUS	UFC1 →	-0.934	-0.278	<.001	<.001	3	4
OESOPHAGUS	SELENBP1 →	-3.544	-0.335	<.001	<.001	3	4
BREAST	RORC →	-1.844	-1.089	.006	<.001	3	4
BREAST	GPR160 →	-2.038	-0.720	<.001	.002	3	4
BREAST	EID2B →	+0.984	+1.123	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006353 vs INHBB — OESOPHAGUS

Explore this scatter interactively →