DNA-templated transcription initiation

Across TCGA patient cohorts, RNA activity of the DNA-templated transcription initiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, PHF3, and RAD21, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated transcription initiation activity versus SMC1A in HNSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMC1A →	+0.254	+0.057	<.001	.001	3	7
LSCC	PHF3 →	+0.316	+0.041	<.001	<.001	3	7
LSCC	RAD21 →	+0.318	+0.046	<.001	<.001	3	7
GBM	BRD3 →	+0.344	+0.031	<.001	.001	3	7
LSCC	CELF1 →	+0.373	+0.043	<.001	<.001	3	7
LSCC	SF1 →	+0.183	+0.030	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006352 vs SMC1A — HNSC

Explore this scatter interactively →