DNA-templated transcription initiation

Across TCGA cell cohorts, RNA activity of the DNA-templated transcription initiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM17, DPY19L3, and TM7SF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM17 grouped by DNA-templated transcription initiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RBM17 →	-0.910	-0.161	.009	.008	3	4
PANCREAS	DPY19L3 →	-0.910	-0.119	.004	.003	3	4
LIVER	TM7SF3 →	+0.778	+0.249	.003	.002	3	4
OVARY	SLC38A6 →	+0.731	+0.116	.001	.001	3	4
LUNG_NSCLC_LUAD	UBE3C →	+0.683	+0.126	.001	.009	3	4
KIDNEY	MMP14 →	+2.063	+0.180	.006	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM17 by DNA-templated transcription initiation activity — BLOOD_Myeloma

Explore this box plot interactively →