DNA replication-dependent chromatin assembly

Across TCGA patient cohorts, RNA activity of the DNA replication-dependent chromatin assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, RFC2, and RRM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA replication-dependent chromatin assembly activity versus RFC1_T506 in LUAD (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+1.163	+0.128	<.001	<.001	3	10
LSCC	RFC2 →	+0.433	+0.101	<.001	<.001	3	10
LUAD	RRM2 →	+0.926	+0.113	<.001	<.001	3	10
UCEC	SMC2 →	+0.774	+0.094	<.001	<.001	3	10
UCEC	SMC4 →	+0.714	+0.106	<.001	<.001	3	10
LUAD	TK1 →	+0.653	+0.109	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006335 vs RFC1_T506 — LUAD

Explore this scatter interactively →