DNA replication-dependent chromatin assembly

Across TCGA patient cohorts, RNA activity of the DNA replication-dependent chromatin assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25C, SKA3, and SGO1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA replication-dependent chromatin assembly activity versus CDC25C in GBM (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDC25C →	+0.995	+1.145	<.001	<.001	3	9
UCEC	SKA3 →	+1.095	+1.136	<.001	<.001	3	9
GBM	SGO1 →	+0.814	+1.099	<.001	<.001	3	9
GBM	CHEK1 →	+1.002	+1.410	<.001	<.001	3	9
GBM	MCM4 →	+0.867	+1.753	<.001	<.001	3	8
UCEC	TTK →	+1.302	+1.102	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006335 vs CDC25C — GBM

Explore this scatter interactively →