Mitotic recombination

Across TCGA patient cohorts, RNA activity of the Mitotic recombination pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1106, PES1, and NIP7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic recombination activity versus TOP2A_S1106 in LUAD (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1106 →	+1.075	+0.045	<.001	<.001	3	9
LSCC	PES1 →	+0.293	+0.049	<.001	<.001	3	9
BRCA	NIP7 →	+0.564	+0.036	<.001	.001	3	9
BRCA	RSF1_S397 →	+1.045	+0.045	<.001	<.001	3	8
GBM	SMC2 →	+0.565	+0.052	<.001	<.001	3	8
GBM	SUPT6H →	+0.301	+0.065	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006312 vs TOP2A_S1106 — LUAD

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