DNA catabolic process

Across TCGA patient cohorts, RNA activity of the DNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPU, NDUFS5, and PDE2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA catabolic process activity versus CENPU in COAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPU →	+0.505	+0.172	.006	.003	3	4
LUAD	NDUFS5 →	+0.430	+0.183	<.001	.002	3	4
GBM	PDE2A →	-0.982	-0.147	<.001	.003	3	4
GBM	CHGA →	-1.222	-0.127	<.001	<.001	3	3
GBM	SNRPC →	+0.224	+0.134	.005	.001	3	3
LUAD	MED20 →	+0.378	+0.140	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006308 vs CENPU — COAD

Explore this scatter interactively →