DNA catabolic process

Across TCGA cell cohorts, RNA activity of the DNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISG20, TREX1, and EXOG, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA catabolic process activity versus ISG20 in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ISG20 →	+1.970	+0.064	<.001	<.001	3	9
BREAST	TREX1 →	+1.049	+0.060	<.001	<.001	3	9
LUNG_NSCLC_LUAD	EXOG →	+0.803	+0.066	<.001	<.001	3	6
BLOOD_Lymphoma	SETMAR →	+0.891	+0.048	.003	.005	3	6
BLOOD_Leukemia	ASB6 →	+0.589	+0.056	<.001	<.001	3	6
BLOOD_Leukemia	ENDOG →	+0.572	+0.038	.004	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006308 vs ISG20 — BLOOD_Leukemia

Explore this scatter interactively →