Postreplication repair

Across TCGA cell cohorts, RNA activity of the Postreplication repair pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPD1, EIF5A, and MRPL42, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postreplication repair activity versus HSPD1 in KIDNEY (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HSPD1 →	+1.021	+0.253	.006	.006	3	7
OVARY	EIF5A →	+1.083	+0.226	<.001	.006	3	7
OVARY	MRPL42 →	+0.756	+0.359	<.001	<.001	3	7
OVARY	NOP14 →	+0.790	+0.251	.009	.004	3	7
KIDNEY	LYPD3 →	-0.364	-0.246	<.001	<.001	3	6
OVARY	MRPS27 →	+1.104	+0.308	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006301 vs HSPD1 — KIDNEY

Explore this scatter interactively →