"Base-excision repair, AP site formation"

Across TCGA cell cohorts, RNA activity of the "Base-excision repair, AP site formation" pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPG, MFSD10, and CLCN7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Base-excision repair, AP site formation" activity versus MPG in OVARY (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MPG →	+1.150	+0.652	.001	.002	3	7
OVARY	MFSD10 →	+1.139	+0.565	<.001	<.001	3	4
BLOOD_Leukemia	CLCN7 →	+1.101	+0.672	.001	.009	3	3
BLOOD_Leukemia	STUB1 →	+0.552	+0.457	.001	.003	3	3
BLOOD_Leukemia	COQ10B →	-0.497	-0.512	.001	.004	3	3
BLOOD_Leukemia	MLST8 →	+0.572	+0.636	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006285 vs MPG — OVARY

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