Base-excision repair

Across TCGA patient cohorts, RNA activity of the Base-excision repair pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and SSRP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Base-excision repair activity versus SMC2 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC2 →	+0.558	+0.083	<.001	.001	3	9
LUAD	SMC4 →	+0.530	+0.056	<.001	<.001	3	9
LSCC	SSRP1 →	+0.429	+0.066	.001	<.001	3	9
UCEC	UBE2T →	+0.604	+0.071	<.001	.004	3	9
GBM	GINS3 →	+0.653	+0.038	<.001	<.001	3	9
LUAD	LIG1 →	+0.422	+0.055	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006284 vs SMC2 — UCEC

Explore this scatter interactively →