Regulation of DNA repair

Across TCGA patient cohorts, RNA activity of the Regulation of DNA repair pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, TOP2A_S1377, and ZMYM4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA repair activity versus TOP2A_S1247 in HNSC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2A_S1247 →	+1.054	+0.066	<.001	<.001	3	8
PDAC	TOP2A_S1377 →	+1.320	+0.034	<.001	<.001	3	8
HNSC	ZMYM4 →	+0.309	+0.072	<.001	.001	3	8
LSCC	ADNP →	+0.328	+0.029	<.001	<.001	3	8
PDAC	DDX52 →	+0.287	+0.022	.004	.003	3	8
LSCC	GTF3C4 →	+0.341	+0.045	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006282 vs TOP2A_S1247 — HNSC

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