RNA-templated DNA biosynthetic process

Across TCGA cell cohorts, RNA activity of the RNA-templated DNA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAPC1, NECTIN4, and LAPTM4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNAPC1 grouped by RNA-templated DNA biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SNAPC1 →	+1.502	+0.136	.006	.004	3	5
KIDNEY	NECTIN4 →	+1.828	+0.287	.007	<.001	3	4
URINARY_TRACT	LAPTM4A →	+1.189	+0.389	<.001	<.001	3	4
LIVER	BMF →	-2.372	-0.252	.004	.006	3	4
LUNG_NSCLC_LUSC	CRISPLD2 →	+1.866	+0.220	<.001	.002	3	4
LUNG_NSCLC_LUSC	P4HA2 →	+3.060	+0.257	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNAPC1 by RNA-templated DNA biosynthetic process activity — OVARY

Explore this box plot interactively →