DNA strand elongation involved in DNA replication

Across TCGA cell cohorts, RNA activity of the DNA strand elongation involved in DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF738, YEATS2, and HMGB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand elongation involved in DNA replication activity versus ZNF738 in BLOOD_Myeloma (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF738 →	+2.310	+0.158	<.001	<.001	3	8
BLOOD_Lymphoma	YEATS2 →	+0.837	+0.153	.005	.001	2	8
BLOOD_Lymphoma	HMGB2 →	+0.823	+0.095	<.001	.009	3	6
BLOOD_Leukemia	NELFA →	+0.689	+0.149	<.001	<.001	3	6
BLOOD_Lymphoma	MCM7 →	+1.017	+0.147	.001	<.001	3	6
KIDNEY	ZNF724 →	+0.880	+0.255	.002	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006271 vs ZNF738 — BLOOD_Myeloma

Explore this scatter interactively →