DNA replication initiation

Across TCGA patient cohorts, RNA activity of the DNA replication initiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGO1, CDC25A, and BRCA1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA replication initiation activity versus SGO1 in UCEC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SGO1 →	+0.831	+0.416	<.001	<.001	3	9
GBM	CDC25A →	+0.936	+0.443	<.001	<.001	3	9
LSCC	BRCA1 →	+0.763	+0.428	<.001	<.001	3	8
GBM	CENPH →	+0.905	+0.443	<.001	<.001	3	8
GBM	KIF18B →	+1.091	+0.526	<.001	<.001	3	8
UCEC	FBXO5 →	+0.774	+0.506	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006270 vs SGO1 — UCEC

Explore this scatter interactively →