DNA replication initiation

Across TCGA pan-cancer cohorts, RNA activity of the DNA replication initiation pathway is associated with patient survival in 30 of 34 cancer lineages. Pathway activity is summarized from the expression of its 37 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher DNA replication initiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and OV, show the opposite pattern, with higher activity associated with better survival.

MESO, KIRC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.358	0.699	<.001	150	view →
KIRC	DFS	Median	All	0.557	0.681	<.001	112	view →
KIRP	OS	Tertile	All	0.529	0.806	<.001	111	view →
ACC	OS	Median	All	0.743	0.984	<.001	104	view →
LIHC	DFS	Median	All	0.440	0.625	<.001	92	view →
KICH	DFS	Median	All	0.639	0.951	<.001	74	view →
PAAD	DFS	Quartile	All	0.358	0.629	<.001	57	view →
LGG	DFS	Median	All	0.648	0.800	<.001	53	view →
UCS	OS	Median	II,III,IV	0.609	0.223	.002	50	view →
SARC	OS	Median	All	0.427	0.711	<.001	36	view →
UCEC	DFS	Median	All	0.799	0.877	.006	30	view →
LUAD	OS	Tertile	All	0.617	0.764	<.001	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

GO:0006270–MESO (OS)

Open the MESO breakdown →