DNA replication initiation

Across TCGA cell cohorts, RNA activity of the DNA replication initiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEMP1, GABPB2, and GPATCH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEMP1 grouped by DNA replication initiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NEMP1 →	-1.026	-0.215	.001	<.001	3	5
BONE	GABPB2 →	+0.917	+0.181	.006	<.001	2	5
PANCREAS	GPATCH2 →	-0.494	-0.135	<.001	.008	3	4
CNS	SLC26A10 →	-0.793	-0.151	.004	<.001	3	4
BLOOD_Leukemia	ARL6IP5 →	+0.649	+0.203	<.001	<.001	3	4
LUNG_NSCLC_LUAD	UBFD1 →	-0.517	-0.123	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEMP1 by DNA replication initiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →