DNA replication initiation

Across TCGA cell cohorts, RNA activity of the DNA replication initiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NT5M, POLR3H, and DAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA replication initiation activity versus NT5M in KIDNEY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NT5M →	+0.864	+0.321	.008	.003	3	4
BLOOD_Leukemia	POLR3H →	+0.783	+0.142	<.001	.001	3	3
BLOOD_Leukemia	DAP3 →	-0.373	-0.130	.003	.003	3	3
BLOOD_Leukemia	C1orf162 →	+1.905	+0.115	.001	.001	3	3
BLOOD_Leukemia	SLC25A4 →	-1.610	-0.180	<.001	<.001	3	3
BLOOD_Leukemia	ING5 →	+0.484	+0.119	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006270 vs NT5M — KIDNEY

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