"DNA replication, synthesis of primer"

Across TCGA cell cohorts, RNA activity of the "DNA replication, synthesis of primer" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM184A, BICDL2, and ALS2CL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM184A grouped by "DNA replication, synthesis of primer"-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMEM184A →	+1.351	+0.160	.009	.006	3	6
STOMACH	BICDL2 →	+2.579	+0.159	<.001	.007	3	5
STOMACH	ALS2CL →	+2.143	+0.162	.005	.006	3	5
PANCREAS	NBPF1 →	-0.844	-0.130	.009	.006	3	5
LIVER	C18orf54 →	-0.824	-0.244	.005	.001	3	5
LIVER	ANO9 →	+2.743	+0.221	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM184A by "DNA replication, synthesis of primer" activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →