DNA topological change

Across TCGA patient cohorts, RNA activity of the DNA topological change pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BOP1, ATAD2, and SF3B3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA topological change activity versus BOP1 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BOP1 →	+0.270	+0.040	<.001	<.001	3	9
BRCA	ATAD2 →	+0.472	+0.037	<.001	<.001	3	8
GBM	SF3B3 →	+0.287	+0.059	<.001	<.001	3	8
BRCA	SMC1A →	+0.273	+0.050	<.001	<.001	3	8
LSCC	SMC3 →	+0.242	+0.066	<.001	<.001	3	8
BRCA	UBR5 →	+0.203	+0.044	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006265 vs BOP1 — BRCA

Explore this scatter interactively →