Mitochondrial DNA replication

Across TCGA cell cohorts, RNA activity of the Mitochondrial DNA replication pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENDOG, AVPR1B, and PRMT9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENDOG grouped by Mitochondrial DNA replication-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ENDOG →	-0.436	-0.391	.002	.002	3	6
BONE	AVPR1B →	+0.270	+0.227	.005	.003	3	4
LIVER	PRMT9 →	+0.165	+0.397	.005	<.001	3	4
BLOOD_Lymphoma	DNA2 →	-0.495	-0.649	<.001	.001	3	4
CNS	EPHA2 →	-0.179	-0.206	<.001	.001	3	4
BLOOD_Leukemia	USP20 →	+0.131	+0.156	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENDOG by Mitochondrial DNA replication activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →