DNA replication

Across TCGA cell cohorts, RNA activity of the DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC5, PIAS3, and CLTB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARPC5 grouped by DNA replication-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ARPC5 →	+1.221	+0.228	.002	.001	3	6
UPPER_AERODIGESTIVE_TRACT	PIAS3 →	+1.058	+0.134	.001	.004	3	5
STOMACH	CLTB →	+1.354	+0.172	.003	.008	3	5
OESOPHAGUS	FAM214B →	+1.263	+0.118	<.001	.001	3	5
BREAST	LYST →	+0.943	+0.149	.002	.003	3	5
KIDNEY	CNIH4 →	+0.794	+0.201	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARPC5 by DNA replication activity — SOFT_TISSUE

Explore this box plot interactively →