DNA replication

Across TCGA cell cohorts, RNA activity of the DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNB1, UHRF1, and KIF18B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA replication activity versus KPNB1 in PANCREAS (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KPNB1 →	+1.058	+0.324	.003	<.001	3	8
BLOOD_Leukemia	UHRF1 →	+1.579	+0.176	<.001	<.001	3	8
PANCREAS	KIF18B →	+1.275	+0.240	.008	.001	3	8
SKIN	SF1 →	+0.716	+0.201	<.001	<.001	3	8
BLOOD_Leukemia	RAD54L →	+0.891	+0.188	<.001	<.001	3	8
PANCREAS	ILF3 →	+0.543	+0.183	.007	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006260 vs KPNB1 — PANCREAS

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