DCMP catabolic process

Across TCGA patient cohorts, RNA activity of the DCMP catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, AGAP1_S521, and AHNAK2_S5707, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DCMP catabolic process activity versus UPP1 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UPP1 →	+0.784	+0.076	<.001	<.001	3	7
BRCA	AGAP1_S521 →	-0.534	-0.083	<.001	.001	3	6
LSCC	AHNAK2_S5707 →	+1.288	+0.114	<.001	<.001	3	6
GBM	EHBP1L1 →	+0.511	+0.111	<.001	<.001	3	6
GBM	MYO1E →	+0.355	+0.084	<.001	<.001	3	6
GBM	RUNX1_T14 →	+0.862	+0.162	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006249 vs UPP1 — GBM

Explore this scatter interactively →