DCMP catabolic process

Across TCGA patient cohorts, RNA activity of the DCMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL21R, ARHGDIB, and UPP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DCMP catabolic process activity versus IL21R in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL21R →	+1.025	+0.113	<.001	.004	3	7
LSCC	ARHGDIB →	+0.673	+0.132	.001	.002	3	7
GBM	UPP1 →	+0.894	+0.139	.001	<.001	2	7
CCRCC	FES →	+0.394	+0.102	<.001	.002	3	6
PDAC	CYTOR →	+0.418	+0.131	<.001	<.001	3	6
OV	PRKAR1B-AS1 →	+0.660	+0.167	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006249 vs IL21R — GBM

Explore this scatter interactively →