DCMP catabolic process

Across TCGA cell cohorts, RNA activity of the DCMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP8B, TMEM43, and PXN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP8B grouped by DCMP catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BMP8B →	-1.387	-0.815	.006	.008	3	5
CNS	TMEM43 →	+0.980	+1.116	.003	.005	2	6
CNS	PXN →	+0.990	+1.025	.006	.003	3	5
LUNG_NSCLC_LUSC	BAHD1 →	-0.650	-1.638	.008	<.001	3	4
LUNG_NSCLC_LUSC	TOP1 →	+0.791	+1.702	.001	<.001	3	4
BLOOD_Myeloma	DYNC2I1 →	+1.490	+2.146	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP8B by DCMP catabolic process activity — SKIN

Explore this box plot interactively →