DCMP catabolic process

Across TCGA cell cohorts, RNA activity of the DCMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA1, RNASEL, and TRIOBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DCMP catabolic process activity versus RASA1 in CNS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RASA1 →	-0.891	-1.035	.002	<.001	3	4
URINARY_TRACT	RNASEL →	-1.627	-1.482	.008	<.001	3	4
URINARY_TRACT	TRIOBP →	-0.720	-1.459	.009	<.001	2	5
SKIN	TSSK4 →	-0.352	-0.490	.004	.006	3	4
LUNG_NSCLC_LUSC	MAML3 →	-1.722	-1.672	.002	<.001	3	4
CNS	TMEM79 →	-0.603	-1.038	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006249 vs RASA1 — CNS

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