Pyrimidine nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR11, HEPH, and AURKB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleotide metabolic process activity versus PRR11 in LSCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRR11 →	+0.341	+0.104	.009	.004	3	5
PDAC	HEPH →	-0.553	-0.133	.001	.002	3	5
UCEC	AURKB →	+0.808	+0.196	.003	.001	3	5
LSCC	RNU7-11P →	+0.950	+0.125	<.001	.007	3	4
OV	IRAG1 →	-0.811	-0.182	.008	.004	2	5
LUAD	CENPI →	+0.517	+0.120	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006220 vs PRR11 — LSCC

Explore this scatter interactively →