Pyrimidine nucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PML, UPP1, and CASP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside metabolic process activity versus PML in LSCC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PML →	+0.422	+0.045	<.001	.002	3	7
LSCC	UPP1 →	+0.448	+0.036	<.001	.004	3	7
BRCA	CASP1 →	+0.358	+0.025	<.001	<.001	3	7
OV	IFI35 →	+0.506	+0.049	<.001	<.001	3	7
GBM	GBP2 →	+0.449	+0.029	.003	.001	3	6
BRCA	SERPINB9 →	+0.546	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006213 vs PML — LSCC

Explore this scatter interactively →