Pyrimidine nucleobase metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleobase metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL23, MYDGF, and MCM6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleobase metabolic process activity versus KLHL23 in LUNG_SCLC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KLHL23 →	+0.666	+0.202	.009	.009	3	5
BLOOD_Leukemia	MYDGF →	-1.352	-0.386	<.001	.003	3	4
LUNG_SCLC	MCM6 →	+0.619	+0.198	.002	.006	3	4
BLOOD_Leukemia	N4BP2 →	+1.419	+0.308	<.001	<.001	3	4
LUNG_SCLC	RFC4 →	+0.567	+0.180	.001	.004	3	4
KIDNEY	TMED9 →	-1.109	-0.259	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006206 vs KLHL23 — LUNG_SCLC

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