CAMP catabolic process

Across TCGA cell cohorts, RNA activity of the CAMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL11, ATXN7L1, and MRPL45, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL11 grouped by CAMP catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPL11 →	+0.510	+1.094	.004	<.001	3	3
SKIN	ATXN7L1 →	-0.726	-0.905	.001	.005	3	3
SKIN	MRPL45 →	+0.306	+0.724	.004	<.001	3	3
BONE	CPEB4 →	-1.762	-1.430	.001	.006	2	4
URINARY_TRACT	ST7 →	-0.781	-1.292	.002	.007	3	3
OESOPHAGUS	GOLGA6L4 →	-0.823	-1.081	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL11 by CAMP catabolic process activity — SKIN

Explore this box plot interactively →