AMP catabolic process

Across TCGA patient cohorts, RNA activity of the AMP catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XDH, UNC13D, and UPP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP catabolic process activity versus XDH in UCEC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XDH →	+1.368	+0.112	<.001	<.001	3	7
GBM	UNC13D →	+0.494	+0.084	.001	.006	3	7
GBM	UPP1 →	+0.545	+0.062	.005	.007	3	7
OV	CASP4 →	+0.797	+0.113	<.001	<.001	3	7
GBM	ITGAM →	+0.620	+0.067	<.001	<.001	3	7
BRCA	RPRD2 →	-0.256	-0.063	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006196 vs XDH — UCEC

Explore this scatter interactively →