GMP biosynthetic process

Across TCGA patient cohorts, RNA activity of the GMP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP36_S73, TOP2A_S1106, and DDX21_S89, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP biosynthetic process activity versus RRP36_S73 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP36_S73 →	+0.797	+0.102	<.001	<.001	3	8
LUAD	TOP2A_S1106 →	+1.020	+0.066	<.001	<.001	3	8
LUAD	DDX21_S89 →	+1.237	+0.094	<.001	<.001	3	8
LUAD	ESF1_S153 →	+0.939	+0.066	<.001	<.001	3	8
LUAD	KPNA2 →	+0.609	+0.065	<.001	<.001	3	8
LUAD	MCM6_S762 →	+1.153	+0.057	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006177 vs RRP36_S73 — UCEC

Explore this scatter interactively →